Related Experiment Video
Updated: Apr 30, 2026
08:07
Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
6.7K
Ewing sarcoma superimposed on a previous osteochondroma in multiple osteochondromatosis
Orthopedics
|April 26, 2014
Summary
Hereditary multiple exostoses patients face increased cancer risk. This case highlights a rare instance of Ewing sarcoma developing in an osteochondroma, a malignancy with a worse prognosis.
Area of Science:
- Orthopedics
- Oncology
- Pathology
Background:
- Hereditary multiple exostoses (HME) increases the risk of malignant transformation in osteochondromas, typically to chondrosarcomas or osteosarcomas.
- Ewing sarcoma is an uncommon bone cancer, rarely reported in association with HME or osteochondromas.
Observation:
- A 13-year-old boy with HME presented with pain and inflammation over a pre-existing osteochondroma.
- Imaging revealed osteolysis, periosteal reaction, cortical erosion, and soft tissue extension, raising suspicion for malignancy.
Findings:
- Biopsy confirmed the presence of Ewing sarcoma within the osteochondroma.
- This represents a rare case of Ewing sarcoma superimposed on an osteochondroma in a patient with HME.
Implications:
- This case underscores the importance of considering Ewing sarcoma in HME patients presenting with concerning osteochondroma changes.
- Ewing sarcoma associated with HME may have a higher grade and poorer prognosis compared to other HME-associated malignancies.
Related Concept Videos
01:24Bone Formation by Endochondral Ossification
14.6K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
14.6K
01:29Bone Disorders
8.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
8.0K
01:03Rous Sarcoma Virus (RSV) and Cancer
5.2K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.2K
01:03Rous Sarcoma Virus (RSV) and Cancer
5.0K
5.0K
01:19Bones of the Upper Limb: Humerus
11.3K
The upper limb consists of the arm, forearm, wrist, and hand bones. The humerus is the single bone of the upper arm region. Proximally, it has a large, spherical, smooth head that articulates with the glenoid cavity of the scapula to form the glenohumeral or shoulder joint. The margin of the head is the anatomical neck, a residual epiphyseal plate. Laterally it extends to form bony projections called the greater tubercle and the lesser tubercle. Next to the tubercles is the surgical neck, a...
11.3K
01:29Bone Formation by Intramembranous Ossification
16.1K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
16.1K