[A case of hepatoid adenocarcinoma of the stomach]

A patient, male, 57 years old, with hepatoid adenocarcinoma of the stomach is reported. Chief complaint was right upper abdominal mass and anorexia for 11 months. The patient's serum AFP level was found to be elevated (652.8 ng/ml) and a mass was observed in left hepatic lobe by isotope scan. It was diagnosed as primary hepatic carcinoma. A large ulcerative tumor (14 x 13 x 0.8 cm) in gastric pylorus-antrum and liver metastasis were found by autopsy. Histologically, the tumor, diagnosed as hepatoid adenocarcinoma of the stomach by pathology, was composed of two but closely related to well differentiated tubular papillary adenocarcinoma and differentiated hepatoid adenocarcinoma. Histogenesis, production of AFP and its significance, and clinicopathologic characteristics of this tumor are discussed with review of literature.