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Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
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Effects of statins-use for patients with aneurysmal subarachnoid hemorrhage: a meta-analysis of randomized controlled

Shao-Hua Su1, Wei Xu2, Jian Hai3

  • 11] The Department of Neurosurgery, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China [2].

Scientific Reports
|April 26, 2014
PubMed

Insights

Statins may reduce mortality in aneurysmal subarachnoid hemorrhage (aSAH) patients, though evidence for preventing vasospasm or poor outcomes is inconclusive. Further research is needed to clarify their role in aSAH management.

Area of Science:

  • Neurology
  • Clinical Trials
  • Pharmacology

Background:

  • Aneurysmal subarachnoid hemorrhage (aSAH) frequently leads to cerebral vasospasm and delayed ischemic neurological deficit (DIND), contributing to significant morbidity and mortality.
  • The therapeutic role of statins in managing patients following aSAH remains a subject of ongoing debate and investigation.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the efficacy and safety of statins in patients diagnosed with aSAH.
  • To assess the impact of statins on key outcomes including vasospasm, DIND, neurological outcomes, and mortality.

Main Methods:

  • A meta-analysis was performed on data pooled from six randomized controlled trials (RCTs), involving a total of 249 patients with aSAH.
  • Statistical analyses included calculating risk ratios (RR) with 95% confidence intervals (CI) and assessing heterogeneity using I² statistics.

Main Results:

  • Statins did not significantly decrease the incidence of vasospasm (RR, 0.80; 95% CI, 0.54-1.17) or poor neurological outcomes (RR, 0.94; 95% CI, 0.77-1.16).
  • A significant reduction was observed in the occurrence of delayed ischemic neurological deficit (DIND) (RR, 0.58; 95% CI, 0.37-0.92) and mortality (RR, 0.30; 95% CI, 0.14-0.64).
  • No significant difference was found in the incidence of potential side effects (RR, 2.49; 95% CI, 0.75-8.33).

Conclusions:

  • While statins are not currently considered standard care for aSAH, the findings suggest a potential benefit in reducing mortality.
  • The observed reduction in DIND warrants further investigation into the neuroprotective mechanisms of statins in the context of aSAH.

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