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Related Experiment Video

Updated: Apr 30, 2026

Iris Fixation via External Pentagram Suturing

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

Bilateral diffuse uveal melanocytic proliferation with multiple iris cysts.

Anthony Joseph¹, Ehsan Rahimy², David Sarraf³

¹Retinal Disorders and Ophthalmic Genetics Division, Jules Stein Eye Institute, University of California, Los Angeles.

JAMA Ophthalmology

|April 26, 2014

Summary

Bilateral diffuse uveal melanocytic proliferation (BDUMP), a rare paraneoplastic syndrome, can present with unusual iris and ciliary body cysts. This case highlights the importance of advanced imaging for diagnosing anterior uveal tract involvement in BDUMP.

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Area of Science:

Ophthalmology
Oncology

Background:

Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a rare paraneoplastic syndrome.
Characteristic findings include exudative retinal detachment, cataracts, and uveal melanocytic tumors.

Observation:

A woman in her 50s with endometrial cancer presented with decreased vision.
Slitlamp and ultrasound biomicroscopy revealed bilateral iris and ciliary body cysts.
Subretinal fluid was observed in the left eye, treated with triamcinolone acetonide.

Findings:

This case represents a rare presentation of BDUMP with multiple iris and ciliary body cysts.
High-quality photography and ultrasound biomicroscopy documented these anterior uveal tract findings.
The patient's subretinal fluid resolved after periocular triamcinolone injections.

Implications:

Anterior uveal tract involvement in BDUMP may be more common than previously reported.
Ultrasound biomicroscopy and OCT are valuable for detecting anterior uveal pathology in suspected BDUMP.
Early diagnosis and management of BDUMP are crucial for preserving vision.