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Related Concept Videos

Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
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Methods of Nuclear Reprogramming01:24

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Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
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iPS Cell Differentiation01:22

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Lineage Commitment01:21

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Assessing Cardiomyocyte Subtypes Following Transcription Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts
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Somatic Cell Reprogramming into Cardiovascular Lineages.

Jenny X Chen1, Karolina Plonowska2, Sean M Wu3

  • 1Harvard Medical School, Boston, MA, USA.

Journal of Cardiovascular Pharmacology and Therapeutics
|April 26, 2014
PubMed
Summary
This summary is machine-generated.

Stem cell research explores regenerating heart cells after myocardial infarction. Cellular reprogramming offers potential clinical therapies, but requires further research for efficiency and accuracy.

Keywords:
cardiomyopathiescardiomyopathyheart diseasestem cells therapy

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Area of Science:

  • Cardiovascular Research
  • Regenerative Medicine
  • Cell Biology

Background:

  • Ischemic cardiac disease is a leading cause of mortality globally.
  • The adult mammalian heart has limited self-repair capacity following myocardial infarction.
  • Advances in understanding cell fate determination drive regenerative strategies.

Purpose of the Study:

  • To explore stem cell-based strategies for cardiomyocyte regeneration post-myocardial infarction.
  • To review recent progress in cellular reprogramming for cardiac repair.
  • To assess the clinical potential of cell lineage reprogramming.

Main Methods:

  • Investigating cellular mechanisms of fate determination.
  • Identifying factors for inducing pluripotency in somatic cells.
  • Exploring direct reprogramming of somatic cells into cardiomyocytes.

Main Results:

  • Specific factors have been identified that can induce pluripotent and cardiomyocyte phenotypes.
  • Cellular reprogramming shows promise for future clinical applications in cardiac repair.
  • The field of cell lineage reprogramming is still in its early stages.

Conclusions:

  • Stem cell research and cellular reprogramming offer potential therapeutic avenues for ischemic cardiac disease.
  • Further research is essential to enhance the efficiency and in vivo fidelity of reprogrammed cells.
  • Clinical translation of these regenerative approaches requires significant advancements.