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Ibuprofen dependence: a case report.

F Etcheverrigaray1, M Grall-Bronnec2, M-C Blanchet2

  • 1Center for Evaluation and Information on Pharmacodependence, Clinical Pharmacology Department, University Hospital, Nantes, France.

Pharmacopsychiatry
|April 26, 2014
PubMed
Summary
This summary is machine-generated.

This study reports a rare case of ibuprofen dependence in a 17-year-old patient, who experienced withdrawal symptoms and self-adjusted dosage. Potential mechanisms involving COX-1/COX-2, FAAH, and PPARs are discussed.

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Clinical Case Study

Background:

  • Ibuprofen is a widely prescribed non-steroidal anti-inflammatory drug (NSAID).
  • Dependence or withdrawal symptoms associated with ibuprofen have not been previously reported.
  • The patient was a 17-year-old individual presenting with significant psychological symptoms.

Observation:

  • The patient exhibited symptoms suggestive of pharmacological dependence.
  • She self-adjusted her ibuprofen dosage during treatment.
  • Withdrawal symptoms were observed when dosage was altered.

Findings:

  • The case presents a novel observation of potential ibuprofen dependence.
  • Pharmacological evidence suggests ibuprofen's interaction with cyclooxygenase (COX-1 and COX-2), fatty acid amide hydrolase (FAAH), and peroxisome proliferator-activated receptors (PPARs).
  • These interactions form the basis for hypotheses explaining the observed dependence.

Implications:

  • This case challenges the established understanding of ibuprofen's safety profile.
  • Further research is warranted to investigate the potential for ibuprofen dependence and its underlying mechanisms.
  • Clinicians should be aware of this rare possibility when prescribing ibuprofen, especially in vulnerable populations.