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Related Experiment Videos

Decrease in intestinal permeability to polyethylene glycol 1000 during development in the pig.

B R Weström1, C Tagesson, P Leandersson

  • 1Department of Zoophysiology, University of Lund, Sweden.

Journal of Developmental Physiology
|February 1, 1989
PubMed
Summary
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Intestinal permeability in newborn pigs is high for polyethylene glycols (PEGs) and macromolecules. This permeability significantly decreases after intestinal closure and further reduces with maturation.

Area of Science:

  • Animal Science
  • Gastroenterology
  • Developmental Biology

Background:

  • Postnatal intestinal development involves significant changes in permeability.
  • Understanding the maturation of the gut barrier is crucial for neonatal health.

Purpose of the Study:

  • To investigate changes in intestinal permeability in pigs during postnatal development.
  • To correlate the permeability of polyethylene glycols (PEGs) with macromolecule transmission.

Main Methods:

  • Pigs of different ages (newborn, 36-45h, 22-28 days) were fed PEGs (Mr 766-1338) and macromolecular markers.
  • Serum concentrations of markers were measured after 4 hours to estimate intestinal transmission.
  • PEG and macromolecule permeability were analyzed in relation to age and intestinal closure.

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Main Results:

  • Newborn pigs showed high serum levels of both PEGs and macromolecules.
  • Intestinal closure in 36-45h old pigs led to lower PEG levels, especially for Mr > 1100 Da.
  • By 22-28 days, PEG levels were significantly reduced, decreasing with increasing molecular size.

Conclusions:

  • High intestinal permeability to PEGs and macromolecules in newborn pigs suggests paracellular transport.
  • Intestinal closure and subsequent maturation markedly reduce gut permeability in developing pigs.
  • Specific PEGs (Mr > 1100 Da) can serve as reliable probes for assessing macromolecular transport during gut closure.