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Updated: Apr 30, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
1-Acetyl-5-meth-oxy-4-(phenyl-sulfan-yl)imidazolidin-2-one
Joel T Mague1, Alaa A-M Abdel-Aziz2, Adel S El-Azab3
1Department of Chemistry, Tulane University, New Orleans, LA 70118, USA.
Abstract:
The title compound, C12H14N2O3S, crystallizes with two independent mol-ecules (A and B) in the asymmetric unit. The five-membered imidazolidin-2-one rings in both mol-ecules are twisted about the C-C bond. In the crystal, the A and B mol-ecules are associated via pairs of N-H⋯O hydrogen bonds, forming A-B dimers. These dimers are linked via C-H⋯S hydrogen bonds, forming double dimers, which are in turn linked via C-H⋯O hydrogen bonds forming two-dimensional networks lying parallel to (001). There are also C-H⋯π inter-actions present, which consolide the layers and link them, so forming a three-dimensional structure.

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