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Updated: Apr 30, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
2,5-Di-methyl-phenyl quinoline-2-carboxy-l-ate
E Fazal1, Manpreet Kaur2, Jerry P Jasinski3
1Department of Chemistry, Yuvaraja's College, Mysore 570 005, India.
Abstract:
In the title compound, C18H15NO2, the dihedral angle between the mean planes of the quinoline ring system and the phenyl ring is 78.8 (1)°. The mean plane of the carboxyl-ate group is twisted from the mean planes of the quinoline ring system and phenyl ring by 1.5 (9) and 77.6 (4)°, respectively. In the crystal, mol-ecules are linked by weak C-H⋯O inter-actions, generating C(8) chains along [001]. Weak π-π stacking inter-actions are also observed [centroid-centroid separation = 3.6238 (12) Å].
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