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Autophagy: A novel therapeutic target for hepatocarcinoma (Review)
Zhanggui Wang1, Weidong Han1, Xinbing Sui1
1Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China.
Abstract:
Autophagy is a highly conserved intracellular degradation process and plays an important role in hepatocarcinogenesis. Available data show that autophagy is involved in anti-hepatocarcinoma (HCC) therapies. Autophagy regulation involves a novel target for overcoming therapeutic resistance and sensitizing HCC to currently therapeutic methods. This is a systematic review on the interface of autophagy and the development of HCC and outlining the role of autophagy in current anti-HCC approaches. Understanding the significance of autophagy in anti-HCC therapy may offer a novel therapeutic target for improving anti-cancer efficacy and prolong survival for HCC patients.
Insights
Autophagy, a cellular process, is crucial in liver cancer development and treatment. Targeting autophagy may enhance current therapies and improve survival for hepatocellular carcinoma (HCC) patients.
Area of Science:
- Cellular Biology
- Oncology
- Hepatology
Background:
- Autophagy is a fundamental cellular degradation pathway.
- Autophagy plays a significant role in hepatocarcinogenesis, the development of liver cancer.
- Emerging evidence suggests autophagy's involvement in anti-hepatocellular carcinoma (HCC) therapies.
Purpose of the Study:
- To systematically review the role of autophagy in HCC development.
- To outline autophagy's function in current anti-HCC therapeutic strategies.
- To explore autophagy as a potential target for overcoming therapeutic resistance in HCC.
Main Methods:
- Systematic literature review.
- Analysis of existing data on autophagy and HCC.
- Review of current anti-HCC treatment modalities and their interaction with autophagy.
Main Results:
- Autophagy is implicated in both promoting and suppressing HCC, depending on the context.
- Modulating autophagy can overcome resistance to existing HCC therapies.
- Autophagy influences the efficacy of various anti-cancer treatments for HCC.
Conclusions:
- Autophagy represents a promising therapeutic target for HCC.
- Targeting autophagy can sensitize HCC to conventional treatments.
- Understanding autophagy's role may lead to improved anti-cancer efficacy and prolonged survival for HCC patients.
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