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Related Concept Videos

Cholecystitis01:20

Cholecystitis

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Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...
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Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

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Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

900
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
900
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

28
Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
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Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

26
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80%...
26
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

906
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Related Experiment Video

Updated: Apr 30, 2026

Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis
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Primary sclerosing cholangitis and pregnancy.

Casper Q Kammeijer1, Robert A De Man2, Christianne J M De Groot3

  • 1Department of Obstetrics and Gynecology, Bronovo Hospital, The Hague;

Clinics and Practice
|April 26, 2014
PubMed
Summary

Primary sclerosing cholangitis during pregnancy is rare but manageable. Treatment with ursodeoxycholic acid (UDCA) can improve symptoms and lead to favorable outcomes for mother and child.

Keywords:
pregnancysclerosing cholestasisursodeoxycholic acid.

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Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
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Area of Science:

  • Hepatology
  • Gastroenterology
  • Obstetrics

Background:

  • Primary sclerosing cholangitis (PSC) is a chronic, progressive liver disease.
  • PSC involves inflammation and destruction of bile ducts, potentially leading to liver failure.
  • PSC in pregnancy is exceptionally rare, posing unique clinical challenges.

Observation:

  • A rare case of PSC in pregnancy is presented.
  • The pregnancy was complicated by threatened preterm delivery and worsening cholestasis.
  • The patient received ursodeoxycholic acid (UDCA) for treatment.

Findings:

  • PSC during pregnancy can affect both maternal and fetal health.
  • UDCA treatment can alleviate pruritus (itching) in PSC patients.
  • High-dose UDCA in pregnancy showed a favorable overall outcome but did not prevent stillbirth.

Implications:

  • This case highlights the importance of managing PSC in pregnant patients.
  • Further research is needed on the safety and long-term effects of UDCA in pregnancy.
  • More data is required regarding fetal and neonatal outcomes in PSC pregnancies.