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Related Concept Videos

Appendicitis01:19

Appendicitis

29
Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...
29
Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

4.4K
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
4.4K
Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

2.1K
Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
2.1K
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

936
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
936
Metastasis02:30

Metastasis

5.4K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.4K

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Related Experiment Video

Updated: Apr 30, 2026

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
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Caecal tumour masquerading as an appendicular mass.

Martha Nixon1, Jes Verwey1, Jacob A Akoh1

  • 1Gastroenterology, Surgery & Renal Services Directorate, Plymouth Hospitals NHS Trust, Derriford Hospital, Plymouth, UK.

Clinics and Practice
|April 26, 2014
PubMed
Summary

Prompt diagnosis and management of appendix mass are crucial. Delayed intervention due to comorbidities can lead to advanced cancer and poor prognosis, highlighting the need for early investigation.

Keywords:
appendix masscaecal cancercomputed tomography.

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Area of Science:

  • Gastroenterology
  • Surgical Oncology

Background:

  • Appendix mass management requires accurate diagnosis of underlying pathology.
  • Co-morbidities significantly impact treatment decisions and surgical intervention timing.

Observation:

  • A 65-year-old female presented with right iliac fossa pain and a mass, initially treated as an appendix mass.
  • Surgery was deferred due to severe co-morbidities, leading to a delayed diagnosis of metastatic caecal cancer.
  • The patient later presented with small bowel obstruction and died from metastatic disease.

Findings:

  • Failure of the appendix mass to resolve within four weeks necessitates thorough investigation for malignancy.
  • Delayed diagnosis and treatment due to co-morbidities negatively impact patient prognosis.
  • Prompt intervention for unresolved appendix masses is essential to prevent disease progression.

Implications:

  • This case underscores the importance of a systematic approach to appendix mass evaluation.
  • Early detection and intervention are critical for improving outcomes in patients with potentially malignant appendix masses.
  • Healthcare providers must carefully balance co-morbidities with the urgency of diagnosing and treating appendix masses.