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Children with Down's syndrome display high rates of hyperuricaemia

Ayako Kashima1, Yukie Higashiyama, Masaru Kubota

  • 1Faculty of Human Life and Environment, Nara Women's University, Nara, Japan.

Acta Paediatrica (Oslo, Norway : 1992)
|April 29, 2014
PubMed

Insights

Hyperuricaemia (high uric acid) is common in children with Down syndrome, affecting 32.7% of patients. This early prevalence highlights the need for careful monitoring to prevent future health issues.

Area of Science:

  • Pediatric Endocrinology
  • Genetics and Genetic Diseases
  • Metabolic Disorders

Background:

  • Hyperuricaemia (high blood uric acid) is frequently observed in adults with Down syndrome.
  • Research on hyperuricaemia in pediatric Down syndrome populations is limited.
  • Understanding early prevalence is crucial for long-term health management.

Purpose of the Study:

  • To determine the prevalence of hyperuricaemia in children with Down syndrome.
  • To investigate associations between hyperuricaemia and lifestyle-related laboratory variables.
  • To explore the relationship with nutritional intake in this population.

Main Methods:

  • A comparative study involving 52 pediatric Down syndrome patients (ages 1-15) and age-matched controls.
  • Hyperuricaemia defined as uric acid z-scores > 2.0 based on pediatric reference values.
  • Nutritional intake assessed via 3-day dietary records.

Main Results:

  • Hyperuricaemia was found in 32.7% of Down syndrome patients, significantly higher than controls.
  • Prevalence was notably higher in males.
  • No significant differences in BMI, glucose, insulin, HOMA-IR, or purine intake; HDL cholesterol showed differences.

Conclusions:

  • High rates of hyperuricaemia are present from early childhood in Down syndrome patients.
  • This finding underscores the importance of proactive management in pediatric Down syndrome.
  • Hyperuricaemia is a potential independent risk factor for adult lifestyle-related diseases.
Abstract

Keywords:
Down's syndromeHyperuricaemiaLifestyle-related diseaseNutrient intakeUric acid

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