Related Experiment Video

Updated: Apr 30, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

15.4K

Aortic to brachial pulse pressure amplification as functional marker and predictor of renal function loss in chronic

Siegfried Wassertheurer1, Klaus Burkhardt, Uwe Heemann

  • 1Health & Environment Department, AIT Austrian Institute of Technology, Vienna, Austria; Department of Analysis and Scientific Computing, Vienna University of Technology, Vienna, Austria.

Journal of Clinical Hypertension (Greenwich, Conn.)
|April 29, 2014
PubMed

Insights

Pulse pressure amplification (PPA) is reduced in chronic kidney disease (CKD) patients and predicts worsening renal function. Low PPA indicates a higher risk of renal endpoints in advanced CKD.

Area of Science:

  • Cardiovascular physiology
  • Nephrology
  • Arterial function

Background:

  • Pulse pressure amplification (PPA) is an indicator of large artery function.
  • The role of PPA in the progression of chronic kidney disease (CKD) is not fully understood.
  • CKD affects cardiovascular health, and understanding arterial function is crucial.

Purpose of the Study:

  • To assess the association between PPA and CKD progression.
  • To determine if PPA predicts renal endpoints in patients with CKD stages 2-4.
  • To investigate the relationship between PPA, renal function decline, and renal outcomes.

Main Methods:

  • Longitudinal study of 128 CKD patients (stages 2-4) and 89 controls over 42 months.
  • Measurement of PPA and estimated glomerular filtration rate (eGFR).
  • Cox regression analysis to identify predictors of renal endpoints (50% eGFR loss or renal replacement therapy).

Main Results:

  • CKD patients exhibited reduced PPA compared to controls.
  • Lower PPA was associated with a faster decline in renal function.
  • PPA, eGFR, and proteinuria were significant predictors of renal endpoints.
  • Patients with stage 4 CKD and low PPA had the highest risk of renal endpoints.

Conclusions:

  • PPA is diminished in CKD patients and correlates with declining renal function.
  • Low PPA is a significant predictor of adverse renal outcomes, particularly in advanced CKD.
  • Systolic blood pressure is a key determinant of PPA in the context of CKD.

More Related Videos

Multilevel Microdissection and Functional-Structural Profiling of Human Renal Arterial Branches06:51

Multilevel Microdissection and Functional-Structural Profiling of Human Renal Arterial Branches

Published on: September 5, 2025

778
A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis08:21

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

Published on: October 26, 2020

4.9K

Related Concept Videos

Sites for measuring blood pressure01:21

Sites for measuring blood pressure

Blood pressure measurement is a fundamental clinical procedure, providing crucial data for assessing cardiovascular health. Among the various sites for this measurement, the brachial and popliteal arteries are predominantly utilized due to their accessibility and the reliability of their readings. This lesson delves into the anatomical significance, methodology, and considerations of measuring blood pressure at these locations.
The Brachial Artery: Primary Site for Blood Pressure Measurement
3.9K
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.8K
Assessment of blood pressure in brachial artery(two-step method)01:23

Assessment of blood pressure in brachial artery(two-step method)

Measuring blood pressure is a fundamental skill in healthcare that aids in diagnosing and monitoring hypertension and other cardiovascular conditions. An aneroid sphygmomanometer, commonly used in clinical settings, offers a manual and precise method for blood pressure measurement. The technique for using this instrument involves specific steps that must be carefully executed to ensure accuracy. The following detailed description outlines a two-step technique for assessing blood pressure using...
2.1K
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
1.4K
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
337
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
587