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Photoperiodic variation in substance P induced plasma extravasation in the rat
S J Gibson1, P V Andrews, R D Helme
1National Research Institute of Gerontology and Geriatric Medicine Department of Medicine, University of Melbourne, Mount Royal Hospital, Parkville, Vic. Australia.
Neuropharmacology
|August 1, 1989
Abstract:
Photoperiodic variation in plasma extravasation was examined following exogenous perfusion of substance P over a vacuum-induced blister base on the rat hind footpad. The results showed a generalised suppression of plasma extravasation during the dark or active phase of the light/dark cycle which appears to be independent of the circadian fluctuations in endogenous corticosterone. These findings emphasise the need to consider photoperiodic conditions as a possible source of variability in neurogenic inflammatory responses.