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Metabolic Profiling to Determine Bactericidal or Bacteriostatic Effects of New Natural Products using Isothermal Microcalorimetry
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Targeting mycobacterial proteolytic complexes with natural products
1TB Discovery Research, Infectious Disease Research Institute, Seattle, WA 98102, USA.
Chemistry & Biology
|April 29, 2014
Abstract:
Controlled proteolysis is key to bacterial viability. In this issue of Chemistry & Biology, Gavrish and colleagues characterize a natural product, lassomycin, targeting the Mycobacterium tuberculosis caseinolytic (Clp) protease. Unusually, lassomycin activates ClpC1, inducing ATPase activity and decoupling it from proteolysis.
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