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Related Experiment Videos

Substance P and peripheral inflammatory hyperalgesia.

Meire Nakamura-Craig1, Terence William Smith

  • 1Department of Pharmacology, Wellcome Research Laboratories, Beckenham, Kent BR3 3BS, U.K.

Pain
|July 1, 1989
PubMed
Summary
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Multiple injections of substance P (SP) can cause long-lasting hyperalgesia in rats, sensitizing them to other pain mediators. This suggests SP modulates peripheral inflammatory pain and may be involved in chronic pain conditions.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Pain Research

Background:

  • Substance P (SP) typically induces short-latency hyperalgesia.
  • The role of SP in prolonged inflammatory pain sensitization is not fully understood.

Purpose of the Study:

  • To investigate the long-term hyperalgesic effects of repeated sub-threshold substance P injections.
  • To determine if substance P can sensitize nociceptors to other inflammatory mediators.

Main Methods:

  • Rats were pre-treated with indomethacin.
  • Sub-threshold doses of substance P, prostacyclin, or prostaglandin E2 were repeatedly injected into the hind paw.
  • The effect of an SP antagonist was evaluated.

Main Results:

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  • Multiple sub-threshold SP injections induced long-lasting hyperalgesia and sensitization to SP, dopamine, and prostacyclin.
  • Repeated prostacyclin or prostaglandin E2 injections also caused sensitization.
  • The SP antagonist inhibited the sensitizing effects of SP, prostaglandin E2, and prostacyclin.

    • Conclusions:

    • Substance P acts as a modulator in peripheral inflammatory pain by sensitizing nociceptors.
    • This SP-mediated sensitization enhances responses to SP and other mediators.
    • The findings suggest a role for SP in the development of chronic inflammatory pain.