Neutrophilic dermatoses as systemic diseases.

Area of Science:

• Dermatology
• Immunology
• Internal Medicine

Background:

• Neutrophilic dermatoses (ND) are a group of inflammatory skin disorders.
• Characterized by sterile neutrophil infiltrates in the skin.
• Key clinical forms include Sweet syndrome, pyoderma gangrenosum, erythema elevatum diutinum, and subcorneal pustular dermatosis.

Purpose of the Study:

• To review the clinical spectrum and associations of neutrophilic dermatoses.
• To explore the concept of neutrophilic systemic disease.
• To discuss the potential autoinflammatory nature of ND and therapeutic implications.

Main Methods:

• Literature review of neutrophilic dermatoses.
• Analysis of clinical presentations and associated conditions.
• Discussion of pathogenetic mechanisms and treatment strategies.

Main Results:

• ND encompass diverse clinical entities with distinct associations.
• Associations include hematologic malignancies, inflammatory bowel disease, rheumatoid arthritis, and monoclonal gammopathies.
• Neutrophil infiltration can extend to internal organs, supporting the concept of systemic disease.

Conclusions:

• Neutrophilic dermatoses represent a spectrum of inflammatory conditions with significant systemic implications.
• Their association with other autoinflammatory disorders and response to IL-1 blockade suggest a polygenic autoinflammatory etiology.
• Further research into the pathogenesis and management of ND is warranted.