[Correlation study between ischemic stroke and polymorphism of human leucocyte antigen gene]
Wei Chen1, Huiyu Feng, Mingming Xu
1Department of Geratology, Affiliated Nanshan Hospital, Guangdong Medical College, Shenzhen 518067, China.
Objective:
To explore the correlation between ischemic stroke (IS) and the polymorphism of human leucocyte antigen (HLA) gene.
Methods:
Antigen, allele, haplotype of HLA-A, B, C, DRB1, DQB1 in 94 IS patients and 503 healthy controls were detected by PCR-SBT.
Results:
(1) There were 11 antigens, 17 alleles in HLA-A locus, 20 antigens, 34 alleles in HLA-B locus, 11 antigens, 16 alleles in HLA-C locus, 13 antigens, 26 alleles in HLA-DRB1 locus, 5 antigens, 13 alleles in HLA- DQB1 locus in IS group.(2) The allelic frequency of HLA-A*31: 01 (P = 0.016 9, RR = 2.827) , HLA-B* 37: 01 (P = 0.006 6, RR = 4.613) and HLA-DRB1*11: 06 (P = 0.000 2, RR = 37.981) in the IS patients was higher than that in healthy controls.(3) The haplotypic frequency of HLA-DRB1*11: 06-DQB1*03: 01 (P = 0.001, RR = 38.52) in the IS patients was higher than that in healthy controls.
Conclusion:
The susceptibility association of HLA-B*37: 01, HLA-DRB1*11: 06 and HLA-DRB1*11: 06-DQB1*03: 01 with IS and HLA gene play a genetic role in the occurrence of.
More Related Videos
10:17An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
Published on: November 3, 2010
09:38Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
Related Concept Videos
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Ischemic Stroke ll: Pathophysiology
Ischemic Stroke l: Introduction
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
