Related Experiment Video
Updated: Apr 30, 2026
10:52
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
10.6K
Low-grade B-cell lymphoma presenting primarily in the bone marrow
Kayoko Iwatani1, Katsuyoshi Takata1, Yasuharu Sato1
1Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
Human Pathology
|April 29, 2014
Summary
Low-grade B-cell lymphomas primarily in bone marrow are rare and diverse. This study found varied subtypes, with some "not otherwise specified" cases resembling lymphoplasmacytic or marginal zone lymphomas.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Low-grade B-cell lymphoma (LBCL) primarily in bone marrow is uncommon.
- Clinicopathological features of these rare presentations are not well-defined.
Purpose of the Study:
- To retrospectively analyze the clinicopathology of LBCL presenting primarily in the bone marrow.
- To characterize the subtypes, immunophenotypic features, and genetic mutations in these rare lymphomas.
Main Methods:
- Retrospective review of 14 patients with LBCL primarily in the bone marrow.
- Immunohistochemistry (CD20, CD138, CD10, BCL-2) and fluorescence in situ hybridization (IgH/BCL-2 rearrangement).
- Analysis of myeloid differentiation primary response gene (88) (MYD88) L265P mutation and paraproteinemia.
Main Results:
- Included lymphoplasmacytic lymphoma (LPL), chronic lymphocytic leukemia/small lymphocytic lymphoma, follicular lymphoma (FL), and LBCL-not otherwise specified (LGBCL-NOS).
- MYD88 L265P mutation found in LPL, FL, and LGBCL-NOS.
- Paraproteinemia observed in 10 patients (6 IgM, 3 IgG).
- One LPL patient died from lymphoma progression.
Conclusions:
- LBCL primarily in bone marrow comprises diverse subtypes.
- Approximately one-third of cases were LGBCL-NOS.
- LGBCL-NOS immunophenotype and MYD88 mutation suggest overlap with LPL or marginal zone lymphoma.
Related Concept Videos
01:16Primary Lymphoid Organs
9.6K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
9.6K
01:22Bone Marrow Sampling and Transplants
3.0K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
3.0K
01:23Cells of the Adaptive Immune Response
6.9K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
6.9K
01:27Disorders of Leukocytes
2.3K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
2.3K
01:15Secondary Lymphoid Organs
7.2K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
7.2K