Related Experiment Video
Updated: Apr 30, 2026
13:21
Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
Published on: July 21, 2011
14.6K
Biodegradable iodinated polydisulfides as contrast agents for CT angiography
1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
Biomaterials
|April 29, 2014
Summary
New biodegradable polydisulfide CT contrast agents offer prolonged vascular enhancement and improved safety. These agents degrade into excretable oligomers, potentially preventing contrast-induced nephropathy for better cardiovascular imaging.
Area of Science:
- Biomaterials Science
- Radiology
- Polymer Chemistry
Background:
- Current CT contrast agents are small molecules with short retention and risk of nephropathy.
- Enhanced cardiovascular imaging requires agents with longer blood pool circulation.
Purpose of the Study:
- To develop novel biodegradable macromolecular CT contrast agents.
- To optimize pharmacokinetics and improve the safety profile of iodinated CT agents.
Main Methods:
- Synthesized polydisulfides incorporating iodinated CT contrast agents and polyethylene glycol (PEG) chains.
- Evaluated in vivo pharmacokinetic properties and vascular enhancement in mice.
- Assessed biodegradability and renal excretion pathways.
Main Results:
- Polydisulfide agents demonstrated 5-10 times higher blood pool enhancement than iodixanol in mice.
- Agents exhibited prolonged vascular enhancement due to macromolecular structure.
- Gradual degradation and excretion via renal filtration were observed, indicating reduced nephrotoxicity risk.
Conclusions:
- Biodegradable polydisulfide CT contrast agents offer superior vascular enhancement and prolonged circulation.
- These novel agents show promise as safer alternatives to current agents, potentially preventing contrast-induced nephropathy.
- The developed agents are suitable for CT angiography and image-guided interventions.
Related Concept Videos
01:27Imaging Studies III: Computed Tomography
893
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
893
01:30Radiological Investigation I: X-ray and CT
1.8K
Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
1.8K
01:28Imaging Studies for Cardiovascular System V: CT
671
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
671
01:14Imaging Studies I: CT and MRI
1.3K
Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
1.3K
01:25Imaging Studies II: Positron Emission Tomography and Scintigraphy
853
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Fundamental Principles of PET
853
01:19Imaging Studies VII: Vascular Imaging
558
DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
558