Epicardial linear electroporation ablation and lesion size
Kars Neven1, Vincent van Driel2, Harry van Wessel3
1Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands; Department of Rhythmology, Alfried Krupp Krankenhaus, Essen, Germany.
Heart Rhythm
|April 29, 2014
Summary
Electroporation ablation creates larger myocardial lesions with increased energy delivery. This study confirms a significant relationship between electroporation energy and lesion size without adverse coronary artery effects.
Area of Science:
- Cardiovascular Ablation Technologies
- Electrophysiology
- Medical Device Engineering
Background:
- Electroporation offers nonthermal myocardial tissue ablation.
- Controllability of lesion creation in electrical ablation requires precise energy delivery determination.
Purpose of the Study:
- To investigate the relationship between epicardial electroporation energy magnitude and myocardial lesion size.
- To evaluate the efficacy of a linear suction device for electroporation ablation.
Main Methods:
- Utilized a custom linear suction device with a single electrode for electroporation in pigs.
- Delivered 30, 100, or 300 J of energy to epicardial left ventricular sites.
- Assessed lesion size histologically and monitored coronary arteries via angiography.
Main Results:
- Increased energy levels (30, 100, 300 J) significantly correlated with larger lesion depths and widths.
- Higher energy applications resulted in notable tissue shrinkage.
- No significant arterial narrowing was observed at 3-month follow-up.
Conclusions:
- A significant relationship exists between delivered electroporation energy and myocardial lesion size.
- The linear suction device enables controllable lesion creation with electroporation.
- Electroporation ablation demonstrated safety regarding coronary arteries.
