Related Experiment Video
Updated: Apr 30, 2026

High-speed Video Microscopy Analysis for First-line Diagnosis of Primary Ciliary Dyskinesia
Published on: January 19, 2022
Primary ciliary dyskinesia and humoral immunodeficiency--is there a missing link?
Mieke Boon1, Kris De Boeck1, Mark Jorissen2
1Department of Pediatrics, Pediatric Pulmonology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium.
Background:
Primary ciliary dyskinesia (PCD) and humoral mmunodeficiency (HID) are both rare disorders which cause recurrent upper and lower respiratory tract infections.
Objective:
To examine the concurrence of PCD and HID in a patient cohort with known PCD.
Methods:
Retrospective review of the patient files.
Results:
We describe 11 patients of a cohort of 168 patients with PCD (6.5%) with a combination of PCD and some form of HID. The patients all presented with typical clinical symptoms for PCD, however the role of the concomitant immunological abnormalities is not clear.
Conclusion:
PCD and HID coincided in 6.5% of the patients. We suggest that a common pathophysiological pathway results in both disorders.
Related Concept Videos
Immunodeficiency Diseases
There are three main causes of immunodeficiency...
Humoral Immune Responses
Cytomegalovirus Disease
Cystic Fibrosis: Pathogenesis
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
Microtubules in Signaling
Mechanism of Ciliary Motion
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...

