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Bun/creatinine ratio-based hydration for preventing stroke-in-evolution after acute ischemic stroke
Leng-Chieh Lin1, Jiann-Der Lee2, Yen-Chu Hung3
1Department of Emergency Medicine, Chang Gung Memorial Hospital, Chiayi, Chang Gung University College of Medicine, Taiwan, ROC; Department of Nursing, Chang Gung University Of Science and Technology, Chiayi Campus, Chiayi, Taiwan, ROC.
The American Journal of Emergency Medicine
|April 29, 2014
Summary
Hydration therapy for acute ischemic stroke patients with a high BUN/Cr ratio significantly reduced stroke-in-evolution. This intervention may improve patient outcomes.
Area of Science:
- Neurology
- Nephrology
- Critical Care Medicine
Background:
- Blood urea nitrogen (BUN)/creatinine (Cr) ratio is a predictor of stroke-in-evolution (SIE).
- High BUN/Cr ratio may indicate a need for specific interventions in acute ischemic stroke patients.
Purpose of the Study:
- To investigate the efficacy of hydration therapy in reducing SIE.
- To determine if targeting patients with a BUN/Cr ratio ≥15 impacts SIE occurrence.
Main Methods:
- Prospective interventional study with 189 acute ischemic stroke patients.
- Hydration group received intensive IV saline; control group received standard infusion.
- Endpoint: SIE occurrence within 72 hours of admission.
Main Results:
- Hydration group received significantly more saline (P < 0.001).
- SIE occurred in 9.8% of the hydration group vs. 21.6% in the control group (P = 0.026).
- No significant demographic or clinical differences between groups.
Conclusions:
- Hydration therapy based on presenting BUN/Cr ratio may reduce SIE.
- This approach shows potential for improving prognosis in acute ischemic stroke.
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