Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

33.9K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.9K
Epigenetic Regulation01:37

Epigenetic Regulation

3.9K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.9K
RNA Interference01:23

RNA Interference

28.2K
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
28.2K
RNA Structure01:23

RNA Structure

79.2K
Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
79.2K
RNA Stability01:53

RNA Stability

35.8K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
35.8K
RNA Splicing01:32

RNA Splicing

60.7K
Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
60.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of ergosteroside combined risedronate on fracture healing and BMP-2, BMP-7 and VEGF expression in rats.

Acta cirurgica brasileira·2021
Same author

Administration of Silver Nasal Spray Leads to Nanoparticle Accumulation in Rat Brain Tissues.

Environmental science & technology·2021
Same author

Simultaneous Efficient Decontamination of Bacteria and Heavy Metals via Capacitive Deionization Using Polydopamine/Polyhexamethylene Guanidine Co-deposited Activated Carbon Electrodes.

ACS applied materials & interfaces·2021
Same author

Rational design of walnut-like ZnO/Co<sub>3</sub>O<sub>4</sub> porous nanospheres with substantially enhanced lithium storage performance.

Nanoscale·2021
Same author

The Role of Exhaled Hydrogen Sulfide in the Diagnosis of Colorectal Adenoma.

The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale·2021
Same author

Emphysematous gastritis associated with mucormycosis in a patient with fulminant myocarditis requiring veno-arterial extracorporeal membrane oxygenation.

Revista espanola de enfermedades digestivas·2021
Same journal

Extracellular Vesicles in the Tumor Microenvironment: Diverse Origins, Multifaceted Functions, and Emerging Therapeutic Opportunities.

Translational research : the journal of laboratory and clinical medicine·2026
Same journal

Circ_QRICH1 promotes osteoarthritis progression by sponging miR-214-3p to impact ATF3-mediated chondrocyte ferroptosis.

Translational research : the journal of laboratory and clinical medicine·2026
Same journal

Letter to the Editor: Reflections on "Auricular Vagus Nerve Stimulation Alleviates Cardiac Dysfunction in Takotsubo Syndrome".

Translational research : the journal of laboratory and clinical medicine·2026
Same journal

SynNotch-iNOS CAR-Macrophages Remodel the Tumor Immune Microenvironment and Exhibit Antitumor Efficacy via a CD4<sup>+</sup> T Cell-Dependent Mechanism.

Translational research : the journal of laboratory and clinical medicine·2026
Same journal

Ion channel dysfunction in acute pancreatitis: mechanisms, heterogeneity, and therapeutic prospects.

Translational research : the journal of laboratory and clinical medicine·2026
Same journal

Kv1.3 Modulates Macrophage M2 Polarization via the STAT3 Pathway: A Novel Mechanism and Therapeutic Target for Steroid-Resistant Asthma.

Translational research : the journal of laboratory and clinical medicine·2026
See all related articles

Related Experiment Video

Updated: Feb 10, 2026

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
10:44

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

Published on: May 5, 2023

1.9K

RNA epigenetics.

Nian Liu1, Tao Pan2

  • 1Department of Chemistry, University of Chicago, Chicago, Ill.

Translational Research : the Journal of Laboratory and Clinical Medicine
|April 29, 2014
PubMed
Summary
This summary is machine-generated.

Mammalian RNA molecules undergo chemical modifications like N(6)-methyl-adenosine (m(6)A), the most common type. These modifications, recognized by RNA-binding proteins, add a new layer to epigenetic gene regulation.

More Related Videos

ATAC-Seq Optimization for Cancer Epigenetics Research
07:13

ATAC-Seq Optimization for Cancer Epigenetics Research

Published on: June 30, 2022

5.4K
An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling
08:34

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling

Published on: December 18, 2017

7.0K

Related Experiment Videos

Last Updated: Feb 10, 2026

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
10:44

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

Published on: May 5, 2023

1.9K
ATAC-Seq Optimization for Cancer Epigenetics Research
07:13

ATAC-Seq Optimization for Cancer Epigenetics Research

Published on: June 30, 2022

5.4K
An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling
08:34

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling

Published on: December 18, 2017

7.0K

Area of Science:

  • Molecular Biology
  • Epigenetics
  • RNA Biology

Background:

  • Mammalian messenger RNA (mRNA) and long noncoding RNA (lncRNA) possess numerous posttranscriptional chemical modifications.
  • N(6)-methyl-adenosine (m(6)A) is the most prevalent modification and is reversible by specific enzymes.
  • m(6)A modification is recognized by RNA-binding proteins, influencing mRNA functionality.

Purpose of the Study:

  • To highlight the significance of m(6)A modification in RNA biology.
  • To position RNA modification as a critical epigenetic regulatory mechanism.
  • To explore the functional impact of m(6)A-binding proteins on gene expression.

Main Methods:

  • Analysis of existing literature on RNA modifications.
  • Review of studies on m(6)A identification and enzymatic regulation.
  • Examination of research on RNA-binding proteins and their interaction with m(6)A-modified RNA.

Main Results:

  • m(6)A is the most abundant epitranscriptomic mark in mammalian cells.
  • Specific enzymes catalyze the addition and removal of m(6)A.
  • RNA-binding proteins mediate the functional consequences of m(6)A modifications.

Conclusions:

  • RNA chemical modifications, particularly m(6)A, represent a crucial layer of gene expression regulation.
  • This regulatory mechanism is analogous to established epigenetic processes like DNA methylation and histone modification.
  • Understanding m(6)A is vital for comprehending the full scope of gene regulation in mammals.