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Gout in African Americans.

Eswar Krishnan¹

¹Department of Medicine, Stanford University School of Medicine, Palo Alto, Calif.

The American Journal of Medicine

|April 29, 2014

Summary

African Americans have a lower risk of developing gout and hyperuricemia compared to Caucasians, even after accounting for common risk factors. This finding challenges previous assumptions about gout prevalence in different ethnic groups.

Area of Science:

Epidemiology
Cardiovascular Health
Rheumatology

Background:

Gout risk factors are more prevalent in African Americans than Caucasians.
Previous studies suggest higher gout incidence in African Americans.

Purpose of the Study:

To compare the risk for incident gout between African American and Caucasian men.
To investigate ethnic disparities in gout incidence.

Main Methods:

Analysis of gout incidence in 11,559 Caucasian and 931 African American men (aged 35-57) from the Multiple Risk Factor Intervention Trial.
Seven-year observation period with Cox regression models to adjust for confounding factors like BMI, hypertension, diabetes, and kidney disease.

Main Results:

Keywords:

African American Disparities Gout Incidence Uric acid

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African Americans had a 14% lower prevalence of hyperuricemia at baseline.

After adjusting for risk factors, African American ethnicity was associated with a lower hazard ratio for gout (0.78) and hyperuricemia (0.88).

Ethnic disparities were most pronounced in individuals without other gout risk factors.

Conclusions:

African American ethnicity is linked to a significantly lower risk of gout and hyperuricemia compared to Caucasian ethnicity, after controlling for risk factor prevalence.
Findings indicate a need to re-evaluate ethnic disparities in gout epidemiology.