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Updated: Apr 30, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
MiRNA expression profile reveals a prognostic signature for esophageal squamous cell carcinoma
Zhaoli Chen1, Jiagen Li1, Liqing Tian2
1Departments of Thoracic Surgery, Cancer Hospital and Institute, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Abstract:
In this study, we analyzed the microRNA (miRNA) expression profile of 119 paired ESCC samples by microarray and identified a four-miRNA signature that predicted patient survival. The signature derived from the training set (n=60) had a good prognostic value in the test set (n=59) and the independent cohort (n=58), indicating the replicability of its prognostic value. Furthermore, the stratified analysis showed that the signature could predict the survival of TNM stage II and stage III patients, indicating that the four-miRNA signature could help to more accurately predict ESCC patient survival.
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