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O-GlcNAc signaling in cancer metabolism and epigenetics

Jay Prakash Singh1, Kaisi Zhang2, Jing Wu3

  • 1Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06519, USA; Section of Comparative Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06519, USA.

Cancer Letters
|April 29, 2014
PubMed

Insights

Protein O-GlcNAcylation, the addition of O-GlcNAc sugars to proteins, is crucial for cell regulation. Aberrant O-GlcNAc modification is linked to cancer, impacting cell metabolism and epigenetics.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cancer Research

Background:

  • Protein O-GlcNAcylation (O-GlcNAc) is a dynamic post-translational modification regulating cellular processes.
  • Aberrant O-GlcNAc is implicated in various cancers, affecting key cellular functions.
  • Cancer cell growth depends on metabolic reprogramming and epigenetic alterations.

Purpose of the Study:

  • To review the critical role of O-GlcNAcylation in cancer.
  • To highlight the interplay between cancer metabolism and epigenetics.
  • To discuss the emerging significance of protein O-GlcNAcylation in this context.

Main Methods:

  • Literature review of studies on O-GlcNAcylation, cancer metabolism, and epigenetics.
  • Analysis of the regulatory mechanisms linking O-GlcNAc to cancer progression.
  • Synthesis of current research findings.

Main Results:

  • O-GlcNAcylation modifies signaling proteins, metabolic enzymes, and epigenetic regulators.
  • Altered O-GlcNAc levels are associated with metabolic reprogramming in cancer.
  • O-GlcNAcylation influences the epigenetic landscape, impacting cancer development.

Conclusions:

  • Protein O-GlcNAcylation is a key player at the nexus of cancer metabolism and epigenetics.
  • Understanding O-GlcNAcylation offers potential therapeutic strategies for cancer.
  • Further research is needed to fully elucidate the role of O-GlcNAcylation in cancer.
Keywords:
Cancer metabolismEpigeneticsO-GlcNAcPosttranslational modifications

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