Related Experiment Video
Updated: Apr 30, 2026

Study of Protein Dynamics via Neutron Spin Echo Spectroscopy
Published on: April 13, 2022
A generalized free-solvent model for the osmotic pressure of multi-component solutions containing protein-protein
Devin W McBride1, V G J Rodgers1
1B2K Group (Biotransport & Bioreaction Kinetics Group), Center for Bioengineering Research, Department of Bioengineering, University of California, Riverside, Riverside, CA 92521, United States.
Abstract:
The free-solvent model has been shown to have excellent predictability of the osmotic pressure for single and binary non-interactive proteins in aqueous solutions. Here the free-solvent model is extended to be more generalized by including the contributions of intra- and inter-protein interactions to the osmotic pressure of a solution in the form of homo- and hetero-multimers. The solute-solvent interactions are considered to be unique for each homo- and hetero-multimer in solution. The effect of the various generalized free-solvent model parameters on the osmotic pressure are examined for a single protein solution with a homo-dimer, a binary protein solution with no protein-protein interactions, and a binary protein solution with a hetero-dimer. Finally, the limitations associated with the generalized free-solvent model are discussed.
More Related Videos
Related Concept Videos
Osmotic Pressure
Osmosis and Osmotic Pressure of Solutions
Osmosis
Water, like other substances, moves from a high concentration of...
Osmosis
Physiological Pharmacokinetic Models: Assumption with Protein Binding
Chemical and Solubility Equilibria

