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Interferon-mediated ISG15 conjugation restricts dengue virus 2 replication.

Takayuki Hishiki1, Qi'En Han2, Kei-ichiro Arimoto3

  • 1Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, 14 Medical Drive,Singapore 117599, Singapore; Laboratory of Primate Model, Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, Kyoto 606-8517, Japan.

Biochemical and Biophysical Research Communications
|April 29, 2014
PubMed
Summary

Interferon-inducible ISGylation, a modification by ISG15, suppresses Dengue virus 2 (DENV-2) release. ISG15 acts as a host antiviral factor, reducing infectious DENV-2 particle production.

Keywords:
Antiviral responseDengue virusISG15ISGylationInterferonNon-structural protein

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