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Updated: Apr 30, 2026
Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
Published on: May 22, 2013
Individual telomere length decay in patients with spondyloarthritis
María Tamayo1, Sonia Pértega2, Alejandro Mosquera3
1Genetics Unit, INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), As Xubias, 84, 15006 A Coruña, Spain; Laboratorio de Genética Molecular y Radiobiología, Centro Oncológico de Galicia, c/ Doctor Camilo Veiras n°1, 15009 A Coruña, Spain.
Abstract:
Telomere length was sequentially determined in peripheral blood leukocytes (PBL) from patients with ankylosing spondylitis (AS; n = 44) and psoriatic arthritis (PsA; n = 42) followed through 2.93 ± 0.99 years, using a quantitative PCR (qPCR) assay. The initial telomere size from PsA patients was higher than those with cutaneous psoriasis only (n = 53), possibly due to the inflammatory condition. The qPCR assay was sensitive enough to evidence a significant telomere length shortening in PBL from practically all subjects and PsA patients showed a higher rate of loss of telomere sequence than patients with AS during the follow-up time.
