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Evaluation of plasma chemerin levels in patients with non-dipper blood pressure patterns
Murat Meric1, Korhan Soylu1, Bahattin Avci2
1Department of Cardiology, Ondokuz Mayis University, Faculty of Medicine, Samsun, Turkey.
Insights
Elevated chemerin levels, an inflammatory marker, are linked to non-dipper hypertension. Higher chemerin indicates a higher risk of non-dipping blood pressure patterns.
Area of Science:
- Cardiology
- Inflammation Research
- Hypertension Studies
Background:
- Chemerin is an adipokine involved in inflammation and atherosclerosis.
- Hypertension is associated with inflammation, but the link to blood pressure variability is unclear.
- Investigating chemerin's role in hypertension and blood pressure patterns is crucial.
Purpose of the Study:
- To assess if chemerin levels are higher in non-dipper hypertensive patients compared to dippers and healthy controls.
- To explore the correlation between chemerin and blood pressure variability.
- To determine chemerin's potential as a biomarker for non-dipping hypertension.
Main Methods:
- A study involving 90 participants: 60 hypertensive patients (divided into dippers and non-dippers) and 30 healthy controls.
- Ambulatory blood pressure monitoring (ABPM) was used to classify patients.
- Plasma chemerin concentrations were measured using ELISA, alongside complete blood count and biochemistry.
Main Results:
- Non-dipper patients had significantly higher plasma chemerin levels than dippers and normotensives (p<0.001).
- A chemerin cut-off value of 201.4 ng/ml demonstrated 90% sensitivity and 90% specificity for predicting non-dipping patterns.
- Positive correlations were observed between chemerin levels and all measured ambulatory blood pressure values in hypertensive patients.
Conclusions:
- Chemerin levels are elevated in non-dipper hypertensive individuals.
- Chemerin is positively correlated with blood pressure measurements.
- Chemerin may serve as a potential biomarker for identifying non-dipping hypertension.
Background:
Chemerin is a novel adipokine that plays a role in inflammation and atherosclerosis. Although there are several correlations between hypertension and the inflammatory system, there is still insufficient information about the relationship between blood pressure variability and inflammatory markers. In this study, we aimed to determine whether chemerin levels are elevated in non-dipper patients compared with dippers and healthy controls.
Material And Methods:
This study was composed of a group of 90 patients: 60 hypertensive patients and 30 healthy control subjects (12 males, mean age 53.2 ± 15.4 years). Ambulatory blood pressure monitoring devices (ABPM) were connected to all patients. Using data from the ABPM, hypertensive patients were divided into 2 groups: 30 dipper patients (12 males, mean age 52.5 ± 15.1 years) and 30 non-dipper patients (11 males, mean age 54.6 ± 13.0 years). Complete blood count and biochemistry were measured by standard methods and plasma chemerin concentrations were quantified by ELISA.
Results:
Non-dipper patients demonstrated higher chemerin levels compared to dippers and normotensives (219.7 ± 16.3 vs. 182.4 ± 21.4 ng/ml; 219.7 ± 16.3 vs. 85.4 ± 38.1 ng/ml, respectively, p<0.001 for both comparisons). A receiver operating characteristic curve analysis revealed that the optimal cut-off value for chemerin to predict a non-dipping pattern was 201.4, with 90% sensitivity and 90% specificity. There was a positive correlation between chemerin levels and all ambulatory blood pressure values in all hypertensive patients.
Conclusions:
Chemerin, which plays a role in inflammation and atherosclerosis, was higher in non-dippers compared to dippers and normotensives. Additionally, chemerin shows positive correlations with blood pressure.
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