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Updated: Apr 30, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
Published on: June 8, 2014
[Epidemiology of bone and joint disease - the present and future - . Molecular epidemiology of osteoporosis]
1Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Japan.
Abstract:
Osteoporosis is a common skeletal disease characterized by low bone mineral density (BMD) and microarchitectural deterioration of bone tissue. Osteoporosis increases susceptibility to fracture. Over the last 10 years, genome-wide association studies (GWAS) have identified the single-nucleotide polymorphisms (SNPs) associated with low BMD, osteoporosis and osteoporotic fractures. These SNPs were mapped close to or within the genes, such as Wnt- and RANKL-related genes. In the future, molecular epidemiology of osteoporosis may provide novel candidates for therapeutic targets.
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