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Updated: Apr 30, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
Published on: August 18, 2022
Comedo-like openings in melanoma.
Bruno Simão dos Santos1, Lucia Helena Soares Ribeiro1, Eloisa Leis Ayres1
1Fluminense Federal University, Niterói, RJ, Brazil.
Melanoma can rarely present with comedo-like openings, a feature usually seen in seborrheic keratosis. Dermatologists must look for melanocytic criteria to accurately diagnose melanoma, even with non-melanocytic structures present.
Area of Science:
- Dermatology
- Oncology
- Dermoscopy
Background:
- Melanoma diagnosis relies on identifying specific melanocytic features.
- Pigmented lesions can exhibit diverse dermoscopic structures.
- Distinguishing melanoma from benign lesions is clinically crucial.
Observation:
- A case of melanoma displayed comedo-like openings on dermoscopy.
- Comedo-like openings are typically characteristic of seborrheic keratosis.
- This finding represents an unusual presentation for melanoma.
Findings:
- The presence of non-melanocytic structures does not exclude melanoma.
- Thorough dermoscopic examination is essential for accurate diagnosis.
- Specific criteria for melanocytic lesions should be prioritized.
Implications:
- Dermoscopists must remain vigilant for melanoma, even with atypical features.
- This case highlights the importance of a comprehensive diagnostic approach.
- Accurate melanoma diagnosis is critical for timely treatment and improved patient outcomes.
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