[Near fatal intoxication with the novel psychoactive substance 25C-NBOMe]

Area of Science:

• Toxicology
• Pharmacology
• Emergency Medicine

Background:

• The effects of 25C-NBOMe overdose are not well-documented.
• 25C-NBOMe is a novel psychoactive substance currently legal in many regions.
• Understanding overdose effects is crucial for public health and clinical management.

Observation:

• A case report details a 19-year-old male who self-administered 2 mg of 25C-NBOMe intranasally.
• The patient experienced a generalized seizure within 2 hours, requiring mechanical ventilation due to hypoxia and loss of consciousness.
• Subsequent complications included acute kidney and lung failure, necessitating prolonged intensive care and ventilation support.

Findings:

• A 2 mg intranasal dose of 25C-NBOMe precipitated an acute generalized seizure.
• The patient developed severe multi-organ failure, including acute kidney and lung injury.
• Despite a critical condition requiring extensive medical intervention for 13 days, the patient ultimately recovered without lasting sequelae.

Implications:

• This case highlights the potential for severe toxicity from 25C-NBOMe, even at a dose of 2 mg.
• Clinicians should be aware of the risk of seizures and multi-organ failure in cases of 25C-NBOMe intoxication.
• The findings underscore the need for further research into the toxicology and clinical effects of novel psychoactive substances like 25C-NBOMe.