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Published on: March 14, 2019
High-resolution analysis of DNA copy number alterations in rectal cancer: correlation with metastasis, survival, and
Jérôme Doyen1, Eric Letouzé, Laetitia Marisa
1Department of Radiation Oncology, Centre Antoine-Lacassagne, 33 avenue de Valombrose, 06189, Nice, France, doyen@unice.fr.
Background And Purpose:
This study aimed to determine the candidate genes and chromosomal imbalances capable of predicting occurrences of metastasis in patients with rectal cancer.
Patients And Methods:
Fresh frozen tumor tissues from 80 patients with rectal cancer were prospectively collected and analyzed using Affymetrix HG-U133 Plus 2.0 gene expression arrays and high-resolution Illumina single-nucleotide polymorphism (SNP) arrays. Endpoints of the study were metastasis-free survival (MFS) and cancer-specific survival (CSS).
Results:
The median follow-up was 102 months (1-146). Deletions of 8p and 1p36-35 correlated with worse MFS (p = 0.005 and p = 0.01, respectively) and CSS (p = 0.001 and p = 0.01, respectively). Multivariate analysis identified 8p deletion as an independent prognostic factor for MFS (p = 0.04) and CSS (p = 0.003); 97 genes located on the 8p chromosome were significantly underexpressed in tumors with 8p deletion.
Conclusion:
This study shows for the first time in rectal cancer an independent correlation of 8p deletion with MFS and CSS and highlights potential new tumor suppressor genes.
