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Association between matrix metalloproteinase family gene polymorphisms and ischemic stroke: a meta-analysis

Dan Wen1, Xin Du, Shao-Ping Nie

  • 1Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, 100029, Beijing, China.

Molecular Neurobiology
|April 29, 2014
PubMed

Insights

This meta-analysis found that matrix metalloproteinase (MMP) gene variations, specifically MMP-1 -1607 1G/2G and MMP-3 -1612 5A/6A, are risk factors for ischemic stroke. However, MMP-9 -1562C/T showed no association with the condition.

Area of Science:

  • Genetics
  • Neurology
  • Cardiovascular Medicine

Background:

  • Matrix metalloproteinase (MMP) family gene polymorphisms have been investigated for their association with ischemic stroke.
  • Previous findings on the relationship between MMP gene polymorphisms and ischemic stroke risk are inconsistent and require further clarification.

Purpose of the Study:

  • To conduct a comprehensive meta-analysis to evaluate the association between specific matrix metalloproteinase (MMP) gene polymorphisms and the risk of ischemic stroke.

Main Methods:

  • Systematic literature search of PubMed, Embase, and Cochrane Library databases.
  • Data extraction by two independent reviewers, focusing on MMP-1 -1607 1G/2G, MMP-3 -1612 5A/6A, and MMP-9 -1562C/T polymorphisms.
  • Calculation of pooled odds ratios (OR) with 95% confidence intervals (CI) using dominant and recessive genetic models.

Main Results:

  • Eleven studies comprising 589 cases/494 controls (MMP-1), 1,817 cases/1,731 controls (MMP-3), and 540 cases/547 controls (MMP-9) were included.
  • MMP-1 -1607 1G/2G polymorphism was significantly associated with an increased risk of ischemic stroke (OR = 1.54, 95% CI = 1.16-2.04 under dominant model).
  • MMP-3 -1612 5A/6A polymorphism showed a borderline association with ischemic stroke risk (OR = 1.01, 95% CI = 0.84-1.21 under dominant model).
  • No significant association was found between MMP-9 -1562C/T polymorphism and ischemic stroke risk.
  • No publication bias was detected in the meta-analysis.

Conclusions:

  • The MMP-1 -1607 1G/2G and MMP-3 -1612 5A/6A polymorphisms are identified as risk factors for ischemic stroke.
  • The MMP-9 -1562C/T polymorphism is not associated with ischemic stroke risk.
  • These findings contribute to understanding the genetic susceptibility to ischemic stroke related to MMP gene variations.

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