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Published on: August 14, 2013
Hypolipidemic and hypoglycemic effect of peptide Lys-Glu-Trp-NH(2) in rats with associated metabolic disorders
V V Malinin1, T N Savateeva-Lyubimova, K V Sivak
1Cytomed Medical-Biological Research and Production Complex, St. Petersburg, Russia, vvm-61@mail.ru.
Abstract:
The effect of peptide Lys-Glu-Trp-NH2 in doses of 0.2, 20, and 2000 μg/kg on lipid and carbohydrate metabolism was studied in Wistar rats with experimental hyperlipidemia and diabetes mellitus. This tripeptide in a dose of 2000 μg/kg produced a hypolipidemic effect on atherogenic lipoproteins, decreased the intensity of LPO, improved the state of the antioxidant system, and normalized the content of HDL. Treatment with this tripeptide had a hypolipidemic effect and reduced the severity of specifi c morphofunctional changes in the pancreatic and hepatic tissue.
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