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Updated: Apr 30, 2026
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Generation, Maintenance, and Characterization of Human Pluripotent Stem Cell-derived Intestinal and Colonic Organoids
Published on: July 9, 2021
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Intestinal stem cells and celiac disease.
1Anna Chiara Piscaglia, Endoscopy and Gastroenterology Unit, State Hospital-Republic of San Marino, 47893 Borgo Maggiore, Repubblica di San Marino.
World Journal of Stem Cells
|April 29, 2014
Summary
Intestinal stem cells (ISCs) are crucial for gut regeneration. This review explores their role in celiac disease (CD) and potential therapeutic applications, highlighting knowledge gaps.
Area of Science:
- Gastroenterology
- Stem Cell Biology
- Immunology
Background:
- Intestinal stem cells (ISCs) drive gastrointestinal tract renewal.
- Celiac disease (CD) involves immune responses to gluten, impacting the gut.
- ISC deregulation in CD remains poorly understood.
Purpose of the Study:
- To review the current understanding of ISCs in celiac disease.
- To explore the role of the ISC niche in CD pathogenesis.
- To discuss potential ISC-based therapies for refractory celiac disease.
Main Methods:
- Literature review of studies on ISCs and celiac disease.
- Analysis of the ISC niche and its modulation in CD.
- Evaluation of bone marrow-derived stem cell transplantation in CD.
Main Results:
- Dysfunctional stem cells contribute to various diseases, including cancer and organ failure.
- While advances in CD pathogenesis are significant, ISC modulation is understudied.
- Bone marrow-derived stem cell transplantation shows promise for severe CD cases.
Conclusions:
- ISCs are critical for intestinal homeostasis and regeneration.
- Further research is needed to elucidate ISC deregulation in celiac disease.
- ISC-based therapies, including transplantation, offer potential for managing refractory CD.
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