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Acute Kidney Injury III: Clinical Manifestations01:29

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Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
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Dengue-associated kidney disease.

Karlo J Lizarraga1, Ali Nayer2

  • 1Department of Medicine, University of Miami, USA.

Journal of Nephropathology
|April 29, 2014
PubMed
Summary
This summary is machine-generated.

Dengue, a mosquito-borne viral illness, can cause severe renal complications like acute renal failure. However, most dengue infections and kidney issues are self-limiting, especially with prompt medical attention.

Keywords:
Acute renal failureDengue infectionGlomerulonephritisHematuriaProteinuria

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Area of Science:

  • Virology
  • Infectious Diseases
  • Nephrology

Background:

  • Dengue is a significant global health threat, identified by the WHO as a major tropical and subtropical viral illness.
  • Transmitted by Aedes aegypti mosquitoes, dengue virus is an RNA virus belonging to the Flavivirus genus.

Purpose of the Study:

  • To review the association between dengue infection and renal disorders.
  • To understand the clinical presentation and outcomes of dengue-associated kidney complications.

Main Methods:

  • A comprehensive literature search was conducted using major scientific databases: DOAJ, Google Scholar, PubMed, LISTA, and Web of Science.
  • The search focused on studies reporting dengue infection and its impact on renal function.

Main Results:

  • Dengue infection presents with varying severity, from asymptomatic cases to severe forms like dengue hemorrhagic fever and dengue shock syndrome.
  • Renal complications, including acute renal failure (2-5% of severe cases), proteinuria (up to 74%), and hematuria (up to 12.5%), are associated with severe dengue.
  • Histological findings in dengue-associated glomerulonephritis include mesangial proliferation and immune complex deposition, with rare links to autoimmune kidney disorders.

Conclusions:

  • While severe dengue can lead to serious renal issues, the majority of dengue infections and their associated kidney problems are self-limiting.
  • Prompt diagnosis and management are crucial for improving outcomes in patients with dengue-related renal complications.