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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Protein losing enteropathy in systemic lupus erythematosus
The Journal of the Association of Physicians of India
|April 30, 2014
Summary
Protein losing enteropathy (PLE) is a rare initial manifestation of Systemic Lupus Erythematosus (SLE). This study shows two SLE patients with PLE improved with corticosteroid treatment.
Area of Science:
- Immunology
- Gastroenterology
Background:
- Systemic lupus erythematosus (SLE) is a complex autoimmune disease affecting multiple organ systems.
- Gastrointestinal (GI) manifestations in SLE, though common, rarely include protein losing enteropathy (PLE).
Observation:
- Two patients presented with PLE as the initial manifestation of SLE, exhibiting symptoms like pedal edema mimicking nephrotic syndrome.
- Hypoalbuminemia due to GI protein loss is an uncommon but significant feature of SLE.
Findings:
- Protein losing enteropathy (PLE) can be a rare presenting feature of Systemic Lupus Erythematosus (SLE).
- Diagnostic confirmation involves excluding other causes of hypoalbuminemia and may utilize radio-labeled albumin scans.
- Both presented SLE patients with PLE showed significant improvement with corticosteroid therapy.
Implications:
- Highlights the importance of considering PLE in SLE diagnosis, even as an initial presentation.
- Suggests corticosteroids are an effective treatment for SLE-associated PLE.
- Underscores the diverse clinical spectrum of Systemic Lupus Erythematosus.
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