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Related Concept Videos

Cholecystitis01:20

Cholecystitis

29
Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...
29
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

900
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

906
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
906
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

26
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80%...
26
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

28
Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
28
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

563
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
563

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Related Experiment Video

Updated: Apr 30, 2026

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma
05:22

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma

Published on: February 13, 2026

254

Primary sclerosing cholangitis : an atypical presentation.

Sanjay Kumar Mandal, Lopamudra Mandal, Saumik Datta

    The Journal of the Association of Physicians of India
    |April 30, 2014
    PubMed
    Summary

    Primary sclerosing cholangitis (PSC), a bile duct disease, can rarely present with severe liver issues and eye findings like K-F rings without prior symptoms. This case highlights an unusual initial presentation of PSC.

    Related Experiment Videos

    Last Updated: Apr 30, 2026

    Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma
    05:22

    Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma

    Published on: February 13, 2026

    254

    Area of Science:

    • Hepatology
    • Gastroenterology
    • Ophthalmology

    Background:

    • Primary sclerosing cholangitis (PSC) is a chronic, immune-mediated cholestatic liver disease characterized by inflammation and fibrosis of the bile ducts.
    • PSC typically progresses to cirrhosis and portal hypertension, often preceded by symptoms like fatigue, jaundice, and pruritus.

    Observation:

    • This report details an unusual case of PSC presenting acutely with decompensated liver disease.
    • The patient exhibited K-F rings, a characteristic ocular finding, in the absence of preceding typical PSC symptoms.

    Findings:

    • The case demonstrates a rare initial manifestation of primary sclerosing cholangitis presenting as decompensated liver disease.
    • The presence of K-F rings in this context suggests a potential link between ocular manifestations and severe, unheralded PSC.

    Implications:

    • This case underscores the importance of considering PSC in patients with unexplained decompensated liver disease, even without prior biliary symptoms.
    • Ocular findings like K-F rings may serve as an early indicator or associated feature in atypical PSC presentations.
    • Further research into the early diagnostic markers and varied clinical presentations of PSC is warranted.