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Updated: Apr 30, 2026

Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes
Published on: June 27, 2025
A classification of congenital uterine anomalies predicting pregnancy outcomes
Mio Takami1, Shigeru Aoki, Kentaro Kurasawa
1Perinatal Center for Maternity and Neonate, Yokohama City University Medical Center, Yokohama, Japan.
Objective:
To evaluate pregnancy outcomes in women with uterine anomalies by applying a method for diagnosing and classifying congenital uterine malformations.
Design:
Retrospective study.
Setting:
Tertiary care center.
Population:
Ninety-four women with uterine anomalies who delivered after 22 gestational weeks.
Methods:
Excluding the 14 women with a history of surgery and seven with one endometrial cavity, 73 women with two endometrial cavities were subdivided into those with two external uterine orifices (2-OS subgroup) and those with one external uterine orifice (1-OS subgroup).
Main Outcome Measures:
Pregnancy outcomes, such as preterm birth, abnormal fetal presentation, cesarean delivery and placental abruption.
Results:
The 2-OS subgroup comprised women with a didelphic or complete septate uterus who had a significantly higher rate of cesarean delivery (91% vs. 18%, p < 0.001) than the control group (normal uterine morphology; n = 5763). The 1-OS subgroup comprised women with a bicornuate or incomplete septate uterus who had significantly higher rates of preterm birth (27% vs. 5%, p < 0.001) and placental abruption (14% vs. 0.7%, p < 0.001) than the control group.
Conclusions:
Classification of uterine anomalies by the number of uterine endometrial cavities and external uterine orifices is an easy and reliable means of predicting pregnancy outcomes.
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