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Related Experiment Video

Updated: Apr 30, 2026

Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse

Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse

Published on: October 24, 2018

Multiple organ dysfunction syndrome in humans and animals.

K Osterbur¹, F A Mann, K Kuroki

¹Pittsburgh Veterinary Specialty and Emergency Center, Pittsburgh, PA.

Journal of Veterinary Internal Medicine

|April 30, 2014

Summary

This summary is machine-generated.

Multiple organ dysfunction syndrome (MODS) significantly impacts critically ill patients, causing high mortality. This review details MODS history, human pathophysiology, and its effects on animal organ systems.

Keywords:

Acute respiratory distress syndrome Disseminated intravascular coagulation Multiple organ failure Sepsis

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Area of Science:

Veterinary Medicine
Critical Care Medicine
Comparative Pathology

Background:

Multiple organ dysfunction syndrome (MODS) is a critical condition characterized by impaired homeostasis in acutely ill patients.
MODS leads to significant morbidity and mortality in both human and animal populations.
While human MODS research is advanced, understanding in veterinary medicine remains incomplete.

Purpose of the Study:

To provide a historical overview of MODS.
To elucidate the pathophysiology of MODS in humans.
To comparatively review the impact of MODS on major organ systems in animals.

Main Methods:

Comparative review of existing literature.
Synthesis of information on human MODS history and pathophysiology.
Analysis of organ-specific effects of MODS in animal models and clinical cases.

Main Results:

Established the historical context and evolving understanding of MODS.
Detailed the complex pathophysiological mechanisms underlying MODS in humans.
Identified and described the specific effects of MODS across various organ systems in animals.

Conclusions:

MODS is a critical concern with significant implications for both human and animal health.
Understanding human MODS pathophysiology provides a foundation for investigating animal MODS.
Further comparative research is essential to improve diagnosis and treatment strategies for MODS in animals.