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Adult-onset Still disease with peculiar persistent plaques and papules
A Yoshifuku1, K Kawai, T Kanekura
1Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima, Japan.
Clinical and Experimental Dermatology
|April 30, 2014
Summary
Adult-onset Still disease (AOSD) can present with unusual skin rashes. Persistent, itchy papular lesions with specific histological findings may aid in diagnosing this inflammatory disorder.
Area of Science:
- Rheumatology
- Dermatology
- Internal Medicine
Background:
- Adult-onset Still disease (AOSD) is a rare systemic inflammatory condition.
- Classic AOSD symptoms include fever, arthritis, and a transient rash.
- Atypical skin manifestations are increasingly recognized.
Observation:
- A case of AOSD in a 27-year-old woman with persistent, pruritic papular lesions is presented.
- These lesions were histologically characterized by dyskeratotic keratinocytes in the upper epidermis.
- This presentation differs from the typical evanescent rash of AOSD.
Findings:
- The patient's nonclassic skin rash, featuring pruritic papules and dyskeratotic keratinocytes, is detailed.
- Literature review on nonclassic skin manifestations in AOSD is included.
- Histopathological findings of dyskeratotic keratinocytes are highlighted.
Implications:
- Nonclassic pruritic eruptions may serve as a diagnostic clue for AOSD.
- Recognition of atypical skin findings can improve early diagnosis and management of AOSD.
- This case expands the understanding of dermatological presentations in AOSD.
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