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Bloodstream infections due to Peptoniphilus spp.: report of 15 cases

K Brown1, D Church, T Lynch

  • 1Department of Medicine, University of Calgary, Calgary, AB, Canada.

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|April 30, 2014
PubMed

Insights

Peptoniphilus bloodstream infections (BSI) are rare but significant. This study identified 15 cases, often occurring with other microbes, highlighting the need for awareness in clinical settings.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Clinical Diagnostics

Background:

  • Peptoniphilus spp. are Gram-positive anaerobic cocci (GPAC), previously classified under Peptostreptococcus.
  • GPAC are increasingly recognized as clinically relevant pathogens.

Observation:

  • This study analyzed 15 cases of Peptoniphilus spp. bloodstream infections (BSI) between 2007 and 2011.
  • Patients presented with diverse conditions including pneumonia, preterm delivery, soft tissue infections, and colon or bladder diseases.
  • 16S rDNA sequencing was utilized for bacterial identification.

Findings:

  • Peptoniphilus spp. were identified as a cause of BSI in 15 patients.
  • Nearly half (47%) of the identified BSIs were polymicrobial.
  • Isolates were closely related to Peptoniphilus duerdenii, Peptoniphilus sp. (ATCC 29743), and Peptoniphilus hareii.

Implications:

  • Peptoniphilus spp. represent a rare yet important etiological agent of BSIs.
  • These findings underscore the importance of considering Peptoniphilus in the differential diagnosis of BSIs, particularly in polymicrobial cases.
  • Accurate identification using molecular methods like 16S rDNA sequencing is crucial for understanding the epidemiology and clinical impact of these infections.
Keywords:
16S ribosomal DNA sequencingAnaerobic bacteriaGram-positive cocciPeptoniphilusbacteraemia

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