Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Membrane Proteins

Membrane Proteins

Plasma membranes have integral transmembrane proteins involved in facilitated transport. These proteins are collectively referred to as transport proteins, and they function as either channels for the material or as carriers themselves. Channel proteins have hydrophilic domains exposed to the intracellular and extracellular fluids and a hydrophilic channel through their core that provides a hydrated opening for solutes to pass through the membrane layers. Passage through the channel allows...

Secondary Active Transport

Secondary Active Transport

One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme “pump” embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...

Secondary Active Transport

Secondary Active Transport

One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme "pump" embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...

Potentiometry: Membrane Electrodes

Potentiometry: Membrane Electrodes

Membrane electrodes, also known as p-ion electrodes, use membranes that selectively interact with free analyte ions, generating a potential difference across the membrane. The resulting membrane potential, known as the asymmetry potential, is not zero even when analyte concentrations on both sides of the membrane are equal. The membrane's response is typically not selective to a single analyte but proportional to the concentration of all ions in the sample solution capable of interacting at...

Glucose Transporters

Glucose Transporters

Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Selective membrane wetting of phase-separated giant unilamellar vesicles by coacervate droplets.

Nature communications·2026

Same author

pH-responsive regulation of multiphase coacervate wetting <i>via</i> phase selective enrichment of fatty acids.

Chemical science·2025

Same author

Self-Organization of Microcompartments Powered by Enzyme-Driven Solutal Flows at the Water-Oil Interface.

Journal of the American Chemical Society·2025

Same author

Epigenetic modulation rescues neurodevelopmental deficits in Syngap1<sup>+/-</sup> mice.

Aging cell·2025

Same author

Chemomechanical Self-Oscillatory Microgel Motility in Stratified Chemical Media.

Advanced materials (Deerfield Beach, Fla.)·2024

Same author

p300/CBP KATs Are Critical for Maturation and Differentiation of Adult Neural Progenitors.

ACS chemical biology·2024

Search research articles

Related Experiment Video

Updated: Apr 30, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

Glucose- and pH-responsive charge-reversal surfaces.

B V V S Pavan Kumar¹, Krishnachary Salikolimi, M Eswaramoorthy

¹Nanomaterials and Catalysis Lab, Chemistry and Physics of Materials Unit, Jawaharlal Nehru Centre for Advanced Scientific Research , Jakkur P.O., Bangalore 560064, India.

Langmuir : the ACS Journal of Surfaces and Colloids

|April 30, 2014

Summary

We developed a silica surface with pH and glucose-responsive charge reversal. This dual-responsive system demonstrates controlled chromophore desorption, showing sensitivity to glucose at physiological levels.

More Related Videos

Bridging the Bio-Electronic Interface with Biofabrication

Bridging the Bio-Electronic Interface with Biofabrication

Published on: June 6, 2012

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography

Published on: October 25, 2018

Related Experiment Videos

Last Updated: Apr 30, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

Bridging the Bio-Electronic Interface with Biofabrication

Bridging the Bio-Electronic Interface with Biofabrication

Published on: June 6, 2012

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography

Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography

Published on: October 25, 2018

Area of Science:

Materials Science
Surface Chemistry
Nanotechnology

Background:

Silica surfaces are widely used in various applications.
Developing responsive materials is crucial for advanced technologies.
Controlling surface charge is key for molecular interactions.

Purpose of the Study:

To create a silica surface with dual pH and glucose responsiveness.
To demonstrate charge reversal through heterogeneous functionalization.
To investigate the controlled release of molecules based on environmental stimuli.

Main Methods:

Heterogeneous functionalization of silica surfaces.
Utilizing amine and boronic acid moieties for dual responsiveness.
Employing charged chromophores to demonstrate charge reversal via desorption.

Main Results:

Achieved pH- and glucose-responsive charge reversal on silica.
Unambiguously demonstrated dual responsiveness through chromophore desorption.
Observed concentration-dependent glucose response at physiological levels.

Conclusions:

The functionalized silica surface exhibits controllable dual responsiveness.
This system offers potential for glucose sensing and controlled release applications.
The observed sensitivity to physiological glucose levels is a significant finding.