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Related Experiment Videos

Prostate specific antigen: not detectable despite tumor progression after radical prostatectomy.

D E Goldrath1, E M Messing

  • 1Department of Surgery, University of Wisconsin School of Medicine, Madison 53792.

The Journal of Urology
|October 1, 1989
PubMed
Summary

Prostate specific antigen (PSA) monitoring is valuable for prostate cancer follow-up, but undetectable PSA levels can occur even with documented cancer progression after surgery. Further investigation into these cases is warranted.

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Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2007

Area of Science:

  • Oncology
  • Urology

Background:

  • Radical prostatectomy is a primary treatment for localized prostate cancer.
  • Post-operative monitoring typically involves Prostate Specific Antigen (PSA) testing.

Observation:

  • Two cases of documented prostate cancer progression after radical prostatectomy exhibited undetectable PSA levels.
  • This challenges the assumption that rising PSA always indicates recurrence.

Findings:

  • The study discusses potential biological or technical reasons for undetectable PSA in progressive prostate cancer.
  • This phenomenon highlights limitations in relying solely on PSA for disease surveillance.

Implications:

  • While PSA monitoring remains crucial, it should be integrated with other clinical and imaging follow-up methods.

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  • Further research is needed to understand and manage cases of PSA-negative progression.