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Related Experiment Videos

A method for safe twelve-hour pulmonary preservation.

S H Keshavjee1, F Yamazaki, P F Cardoso

  • 1Department of Surgery, University of Toronto, Ontario, Canada.

The Journal of Thoracic and Cardiovascular Surgery
|October 1, 1989
PubMed
Summary
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Extending lung preservation to 12 hours is possible using low-potassium-dextran solution, significantly improving immediate organ function after transplantation compared to Euro-Collins solution.

Area of Science:

  • Transplantation immunology
  • Organ preservation
  • Surgical innovation

Background:

  • Lung transplantation is limited by donor organ scarcity.
  • Current lung preservation methods allow only 4-6 hours of ischemic time.
  • Extending preservation time is crucial for clinical success.

Purpose of the Study:

  • To evaluate the efficacy of 12-hour lung allograft preservation.
  • To compare two preservation solutions: Euro-Collins and low-potassium-dextran.
  • To assess immediate and delayed lung function post-transplantation.

Main Methods:

  • Canine left lung allografts were preserved for 12 hours using pulmonary artery flush.
  • Two flush solutions were tested: Euro-Collins (Group I) and low-potassium-dextran (Group II).

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  • Lung function was assessed immediately and 3 days post-transplant using inflatable cuffs for independent lung assessment.

    • Main Results:

    • Low-potassium-dextran yielded significantly better immediate lung function (PaO2 509 vs. 111 mmHg).
    • Both solutions resulted in excellent lung function by day 3 post-transplant.
    • No significant differences in pulmonary artery pressure, resistance, or CO2 tension were observed between groups.

    Conclusions:

    • Twelve-hour lung preservation is achievable and reproducible.
    • Low-potassium-dextran solution offers superior immediate post-preservation lung function.
    • Extended preservation times show promise for improving lung transplant outcomes.