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Progression of coronary artery calcification in living kidney donors: a follow-up study

Selma Alagoz1, Deniz Cebi, Canan Akman

  • 1Division of Nephrology, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.

Nephron. Clinical Practice
|April 30, 2014
PubMed

Insights

Coronary artery calcification (CAC) progression was studied in kidney donors. While CAC prevalence increased significantly over time, the rate of progression was not high in carefully selected donors, suggesting good long-term cardiac health.

Area of Science:

  • Nephrology
  • Cardiology
  • Transplantation

Background:

  • Long-term outcomes for living kidney donors require further investigation.
  • Coronary artery calcification (CAC) predicts cardiac risk in the general population.
  • Understanding CAC progression in donors is crucial for assessing long-term donor health.

Purpose of the Study:

  • To evaluate the progression of coronary artery calcification (CAC) in former living kidney donors.
  • To identify predictors of CAC progression in this unique cohort.

Main Methods:

  • Multidetector computed tomography (MDCT) was used to assess CAC in 75 former kidney donors.
  • Baseline and follow-up scans were performed approximately 4.8 years apart.
  • Individual changes in CAC scores were analyzed to determine progression rates.

Main Results:

  • Baseline CAC prevalence was 16%, increasing to 72% at follow-up.
  • Mean CAC score increased from 5.3 to 12.5.
  • CAC progression rates ranged from 18.7% to 26.7%; hypertension, high systolic blood pressure, and increased BMI were associated with progression.

Conclusions:

  • The rate of CAC progression in carefully selected living kidney donors appears to be relatively low.
  • Despite increased prevalence, the progression rate suggests acceptable long-term cardiac risk for donors.
Abstract

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